A search team is preparing to enter an explosion-hit wood treatment works near Macclesfield where four people remain missing.
Smoke is still rising from the devastated four-storey Wood Flour Mills in Tunstall Road, Bosley, which collapsed on Friday.
Pockets of the area are still alight and dogs are being used to search for the missing three men and one woman.
Cheshire Fire and Rescue said it had been a challenging night for crews.
“Firefighters are continuing to use water to cool silos on the site and assess temperatures using thermal image cameras,” the service said.
“Specialist urban search and rescue teams have started initial assessments of the scene.”
On Friday, 35 people were assessed at the scene with four people treated for breathing difficulties and another four people taken to hospitals in Birmingham, Merseyside and Stoke.
One 29-year-old woman sustained serious burns and blast injuries to her head, face, arms and chest.
The Conservative MP for Macclesfield, David Rutley, said there was a “really deep sense of shock” locally.
“It’s something that’s affected most people who live in the village, because they all know somebody that works there…or worked there themselves.”
Fire crews described seeing a “scene of devastation” when they arrived.
The building contained heating oil, kerosene, acetylene and asbestos. There is also a silo containing highly flammable wood flour used for making wood laminate flooring.
The fire service added: “Cheshire’s search dog Bryn and his handler have started initial work on part of the site with other search dogs en route to the site.
“Specialist equipment is being organised to move two vehicles near the factory which were badly damaged in the fire to improve access to the factory.”